Flood defences are being deployed and roads closed due to ongoing rainfall.
Defences against the River Severn have gone up in Frankwell, Shrewsbury; while defences in Coleham Head are due to go up at 18:00 GMT.
It comes as a severe flood warning, meaning a danger to life, has been put in place for the town.
The number of warnings in which flooding is expected in England now stands at 85, along with a further 174 flood alerts.
River levels in Shrewsbury are expected to be the highest seen in 20 years, the Environment Agency said.
Elsewhere in Shropshire, Shrewsbury Fire Station said its water rescue unit and boat crew had been in the Melverley area checking on vulnerable people and those who had been isolated by the flood water.
Wellington Fire Station tweeted that the road between Atcham and Cross Houses was closed due to flooding.
There has also been flooding in the south of the county. Jade Copeland, manager of the White Horse Inn, Clun, said: “The amount of rain we have had has, unfortunately, brought the river back out.
“It is still rising and by the looks of it, it is going to become a lot worse.”
Shropshire Council has enacted its severe weather emergency protocol to provide accommodation to rough sleepers.
It said it would update residents on the flooding situation as it developed.
In Herefordshire, the B4530 Adforton to Walford is closed due to flooding.
Herefordshire and Worcestershire Fire Service crews were also sent to rescue two vehicles from floodwater in Leintwardine.
In Worcestershire, the Hanley Road out of Upton-upon-Severn was closed. In Worcester there is said to be the possibility “of exceptionally high levels by midweek”, higher than those in the aftermath of Storm Dennis.
And at Trescott Ford, in south Staffordshire, police said a vehicle had become stranded in flood water.